Testosterone use and male infertility patient education fact sheet

Testosterone Cypionate Injection USP Uses, Side Effects, Interactions

Hemoglobin and hematocrit levels (to detect polycythemia) should be checked periodically in patients receiving long-term androgen administration. The half-life of testosterone cypionate when injected intramuscularly is approximately eight days. Testosterone cypionate injection, USP, for intramuscular injection, contains testosterone cypionate which is the oil-soluble 17 (beta)-cyclopentylpropionate ester of the androgenic hormone testosterone. Studies have found both an increase and decrease in high-density lipoprotein cholesterol. An increase was found to occur after 3 months increasing further during 12 months (43), after 6 months, (35) or close to 1 year (44). Below is a list of medications that can interact with testosterone cypionate.

TU has the longest carbon side chain, consisting of 11 carbon atoms compared to seven and eight for TC and TE respectively, which accounts for its longer duration of action (39,40). One disadvantage of these formulations is the necessity for IM injection. For TU, levels should be measured prior to each subsequent injection (3). In a randomized, parallel treatment group study of 406 subjects with low serum testosterone, two doses of Vogelxo® were compared to a testosterone patch and placebo gel (36).

The ongoing pharmaceutical marketing blitz promises that does depression cause low testosterone-T treatment can make men feel more alert, energetic, mentally sharp, and sexually functional. An open-label study was performed to examine serum testosterone levels after treatment with IM TU using the approved dosing strategy for a total of nine injections (47). Testosterone levels were measured at baseline and at days 4, 7, 11, 14, 21, 28, 42, 56, and 70 after the third injection and 4, 7, 11, 14, 21, 42, and 70 after the fourth injection. A total of 130 hypogonadal males received treatment, but levels were available for 117. Overall, levels were similar after the third and fourth injections, with a mean Cmax of 813 ng/dL reached by day seven and a mean Cmin between 323 to 339 ng/dL by week 10 after each injection.

It is administered as a deep intragluteal injection by a healthcare provider every 2 to 4 weeks. Testosterone pellets and some testosterone injections are given by a health care provider in a hospital or clinic. If you miss an appointment to get your dose, call to make another appointment as soon as possible. Testosterone may interact with other medicines and supplements.

Read real-life stories from patients who have faced reproductive medicine challenges and come out stronger on the other side. Similar to injectable testosterone, transdermal T gel has its advantages and disadvantages. Check out the pros and cons below to see if this is the right method for you. For more information, check our article on all things testosterone gel. Your doctor may order certain tests to check your body’s response to testosterone injection.

The dose can be adjusted in 30 mg increments up to a maximum of 120 mg or a minimum of 30 mg/day (37). Vogelxo® 1% gel is available in a multi-dose metered pump, unit-dose tubes and packets. Each unit-dose tube or packet contains 50 mg of testosterone/5 g. The multi-dose metered pump provides 12.5 mg of testosterone per actuation. It is recommended to start Vogelxo® at a dose of 50 mg applied once daily to the shoulders or upper arms. Dose adjustments are based on serum testosterone levels measured 14 days after starting therapy. The dose of Vogelxo® can be increased to 100 mg/day to achieve therapeutic serum testosterone levels (35).

Safety and efficacy of DEPO-Testosterone (testosterone cypionate) in men with «age-related hypogonadism» (also referred to as «late-onset hypogonadism») have not been established. This drug has not been shown to be safe and effective for the enhancement of athletic performance. Because of the potential risk of serious adverse health effects, this drug should not be used for such purpose. Testosterone in plasma is 98 percent bound to a specific testosterone-estradiol binding globulin, and about 2 percent is free. Generally, the amount of this sex-hormone binding globulin in the plasma will determine the distribution of testosterone between free and bound forms, and the free testosterone concentration will determine its half-life. The effects of testosterone on muscle and bone involve protein synthesis and are a result of genomic actions of testosterone and, therefore, rather slow.

Testosterone cypionate and testosterone enanthate are both effective when taken for their approved indications. Only use the medication prescribed by you and do not switch between brands without asking a healthcare professional. Doctors may prescribe testosterone injections to treat low testosterone due to certain medical conditions in males. These injections do not cure the underlying condition, but they may help alleviate some of the symptoms. Adverse effects of Fortesta® 2% gel were reported in a controlled multi-center, open 90-day study of 149 hypogonadal patients (31). Most common was skin reactions at site of application (16.1%); 79% were mild and the remainder were moderate.

This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription. When filling your prescription, be sure to call ahead to make sure your pharmacy carries it. If you think you’ve used too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away. Testosterone cypionate is available as the brand-name drug Depo-Testosterone. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in every strength or form as the brand-name drug.

Testosterone is a sex hormone that is made naturally in the body. Medicines that contain testosterone (also known as testosterone replacement therapy or TRT) work by adding more testosterone to a person’s body to help them achieve normal levels. Drug abuse is intentional non-therapeutic use of a drug, even once, for its rewarding psychological and physiological effects. Abuse and misuse of testosterone are seen in male and female adults and adolescents. Testosterone, often in combination with other anabolic androgenic steroids (AAS), and not obtained by prescription through a pharmacy, may be abused by athletes and bodybuilders. There have been reports of misuse by men taking higher doses of legally obtained testosterone than prescribed and continuing testosterone despite adverse events or against medical advice. There have been postmarketing reports of venous thromboembolic events, including deep vein thrombosis (DVT) and pulmonary embolism (PE), in patients using testosterone products, such as testosterone cypionate.